1n1m

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{{STRUCTURE_1n1m| PDB=1n1m | SCENE= }}
{{STRUCTURE_1n1m| PDB=1n1m | SCENE= }}
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'''Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor'''
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===Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor===
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==Overview==
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Dipeptidyl peptidase IV (DPP-IV/CD26) is a multifunctional type II transmembrane serine peptidase. This enzyme contributes to the regulation of various physiological processes, including blood sugar homeostasis, by cleaving peptide hormones, chemokines and neuropeptides. We have determined the 2.5 A structure of the extracellular region of DPP-IV in complex with the inhibitor valine-pyrrolidide. The catalytic site is located in a large cavity formed between the alpha/beta-hydrolase domain and an eight-bladed beta-propeller domain. Both domains participate in inhibitor binding. The structure indicates how substrate specificity is achieved and reveals a new and unexpected opening to the active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 12483204 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12483204}}
==About this Structure==
==About this Structure==
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[[Category: Beta-propeller]]
[[Category: Beta-propeller]]
[[Category: Dimer]]
[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:58:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:58:27 2008''

Revision as of 08:58, 29 July 2008

Image:1n1m.png

Template:STRUCTURE 1n1m

Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor

Template:ABSTRACT PUBMED 12483204

About this Structure

1N1M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog., Rasmussen HB, Branner S, Wiberg FC, Wagtmann N, Nat Struct Biol. 2003 Jan;10(1):19-25. PMID:12483204

Page seeded by OCA on Tue Jul 29 11:58:27 2008

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