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2ms2

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{{STRUCTURE_2ms2| PDB=2ms2 | SCENE= }}
{{STRUCTURE_2ms2| PDB=2ms2 | SCENE= }}
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'''THE REFINED STRUCTURE OF BACTERIOPHAGE MS2 AT 2.8 ANGSTROMS RESOLUTION'''
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===THE REFINED STRUCTURE OF BACTERIOPHAGE MS2 AT 2.8 ANGSTROMS RESOLUTION===
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==Overview==
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Bacteriophage MS2 is an icosahedral virus with 180 copies of a coat protein forming a shell around a single-stranded RNA molecule. The coat protein subunits form a lattice with the triangulation number T = 3. The coat protein has a fold which is different from the fold of all other viral coat proteins so far known. It consists of a five-stranded beta sheet facing the inside of the particle, and a hairpin and two helices on the outside. The crystal structure has been refined at 2.8 A resolution. The final R-factor was 0.189 for reflections with F &gt; 2 sigma, and the root-mean-square deviation from idealized bond lengths and bond angles was 0.015 A and 2.9 degrees, respectively. The three chemically identical conformers A, B and C are largely similar. The B conformer has a unique conformation in one loop, which is involved in 5-fold interactions, while the A and C conformers, which are involved in the quasi-6-fold contacts, are similar throughout the structure. One cis-proline has been identified in the B conformer but the corresponding prolines in A and C are of the trans isomer. This residue is conserved within small RNA coliphages and it is proposed that this isomerization enables a less elongated loop (FG) around the 5-fold axis, thus creating a channel. The extensive dimer contact supports the idea of dimers as initial building blocks. An assembly pathway is proposed where five dimers converge into a pentamer and 12 pentamers are linked together with free dimers creating a complete particle.
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{{ABSTRACT_PUBMED_8254664}}
==About this Structure==
==About this Structure==
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[[Category: Bacteriophage coat protein]]
[[Category: Bacteriophage coat protein]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:11:38 2008''

Revision as of 09:11, 29 July 2008

Image:2ms2.png

Template:STRUCTURE 2ms2

THE REFINED STRUCTURE OF BACTERIOPHAGE MS2 AT 2.8 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8254664

About this Structure

2MS2 is a Single protein structure of sequence from Enterobacterio phage ms2. This structure supersedes the now removed PDB entry 1ms2. Full crystallographic information is available from OCA.

Reference

The refined structure of bacteriophage MS2 at 2.8 A resolution., Golmohammadi R, Valegard K, Fridborg K, Liljas L, J Mol Biol. 1993 Dec 5;234(3):620-39. PMID:8254664

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