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2nz0

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{{STRUCTURE_2nz0| PDB=2nz0 | SCENE= }}
{{STRUCTURE_2nz0| PDB=2nz0 | SCENE= }}
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'''Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)'''
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===Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)===
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==Overview==
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KChIPs coassemble with pore-forming Kv4 alpha subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K(+) channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-A resolution. The structure reveals a unique clamping action of the complex, in which a single KChIP1 molecule, as a monomer, laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner, forming an octamer. The proximal N-terminal peptide of Kv4.3 is sequestered by its binding to an elongated groove on the surface of KChIP1, which is indispensable for the modulation of Kv4.3 by KChIP1, and the same KChIP1 molecule binds to an adjacent T1 domain to stabilize the tetrameric Kv4.3 channels. Taken together with biochemical and functional data, our findings provide a structural basis for the modulation of Kv4 by KChIPs.
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{{ABSTRACT_PUBMED_17187064}}
==About this Structure==
==About this Structure==
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[[Category: Kchip1]]
[[Category: Kchip1]]
[[Category: Kv4 3]]
[[Category: Kv4 3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:05:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:19:09 2008''

Revision as of 09:19, 29 July 2008

Image:2nz0.png

Template:STRUCTURE 2nz0

Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)

Template:ABSTRACT PUBMED 17187064

About this Structure

2NZ0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits., Wang H, Yan Y, Liu Q, Huang Y, Shen Y, Chen L, Chen Y, Yang Q, Hao Q, Wang K, Chai J, Nat Neurosci. 2007 Jan;10(1):32-9. Epub 2006 Dec 24. PMID:17187064

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