2iho

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2iho.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2iho.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2iho| PDB=2iho | SCENE= }}
{{STRUCTURE_2iho| PDB=2iho | SCENE= }}
-
'''Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc'''
+
===Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc===
-
==Overview==
+
<!--
-
MOA, a lectin from the mushroom Marasmius oreades, is one of the few reagents that specifically agglutinate blood group B erythrocytes. Further, it is the only lectin known to have exclusive specificity for Galalpha(1,3)Gal-containing sugar epitopes, which are antigens that pose a severe barrier to animal-to-human organ transplantation. We describe here the structure of MOA at 2.4 A resolution, in complex with the linear trisaccharide Galalpha(1,3)Galbeta(1,4)GlcNAc. The structure is dimeric, with two distinct domains per protomer: the N-terminal lectin module adopts a ricinB/beta-trefoil fold and contains three putative carbohydrate-binding sites, while the C-terminal domain serves as a dimerization interface. This latter domain, which has an unknown function, reveals a novel fold with intriguing conservation of an active site cleft. A number of indications suggest that MOA may have an enzymatic function in addition to the sugar-binding properties.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17442345}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17442345 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17442345}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Winter, H C.]]
[[Category: Winter, H C.]]
[[Category: Beta-trefoil]]
[[Category: Beta-trefoil]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:31:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:25:09 2008''

Revision as of 09:25, 29 July 2008

Image:2iho.png

Template:STRUCTURE 2iho

Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc

Template:ABSTRACT PUBMED 17442345

About this Structure

2IHO is a Single protein structure of sequence from Marasmius oreades. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Marasmius oreades mushroom lectin in complex with a xenotransplantation epitope., Grahn E, Askarieh G, Holmner A, Tateno H, Winter HC, Goldstein IJ, Krengel U, J Mol Biol. 2007 Jun 8;369(3):710-21. Epub 2007 Mar 15. PMID:17442345

Page seeded by OCA on Tue Jul 29 12:25:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2iho"
Personal tools