2f2a

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{{STRUCTURE_2f2a| PDB=2f2a | SCENE= }}
{{STRUCTURE_2f2a| PDB=2f2a | SCENE= }}
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'''Structure of tRNA-Dependent Amidotransferase GatCAB complexed with Gln'''
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===Structure of tRNA-Dependent Amidotransferase GatCAB complexed with Gln===
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==Overview==
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The formation of glutaminyl transfer RNA (Gln-tRNA(Gln)) differs among the three domains of life. Most bacteria employ an indirect pathway to produce Gln-tRNA(Gln) by a heterotrimeric glutamine amidotransferase CAB (GatCAB) that acts on the misacylated Glu-tRNA(Gln). Here, we describe a series of crystal structures of intact GatCAB from Staphylococcus aureus in the apo form and in the complexes with glutamine, asparagine, Mn2+, and adenosine triphosphate analog. Two identified catalytic centers for the glutaminase and transamidase reactions are markedly distant but connected by a hydrophilic ammonia channel 30 A in length. Further, we show that the first U-A base pair in the acceptor stem and the D loop of tRNA(Gln) serve as identity elements essential for discrimination by GatCAB and propose a complete model for the overall concerted reactions to synthesize Gln-tRNA(Gln).
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The line below this paragraph, {{ABSTRACT_PUBMED_16809541}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16809541 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16809541}}
==About this Structure==
==About this Structure==
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[[Category: Amidotransferase]]
[[Category: Amidotransferase]]
[[Category: Trna]]
[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:22:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:28:17 2008''

Revision as of 09:28, 29 July 2008

Image:2f2a.png

Template:STRUCTURE 2f2a

Structure of tRNA-Dependent Amidotransferase GatCAB complexed with Gln

Template:ABSTRACT PUBMED 16809541

About this Structure

2F2A is a Protein complex structure of sequences from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Ammonia channel couples glutaminase with transamidase reactions in GatCAB., Nakamura A, Yao M, Chimnaronk S, Sakai N, Tanaka I, Science. 2006 Jun 30;312(5782):1954-8. PMID:16809541

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