1mx9

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[[Image:1mx9.gif|left|200px]]
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{{Seed}}
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[[Image:1mx9.png|left|200px]]
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{{STRUCTURE_1mx9| PDB=1mx9 | SCENE= }}
{{STRUCTURE_1mx9| PDB=1mx9 | SCENE= }}
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'''Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue'''
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===Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue===
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==Overview==
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We present the first crystal structures of a human protein bound to analogs of cocaine and heroin. Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes the hydrolysis of heroin and cocaine, and the detoxification of organophosphate chemical weapons, such as sarin, soman and tabun. Crystal structures of the hCE1 glycoprotein in complex with the cocaine analog homatropine and the heroin analog naloxone provide explicit details about narcotic metabolism in humans. The hCE1 active site contains both specific and promiscuous compartments, which enable the enzyme to act on structurally distinct chemicals. A selective surface ligand-binding site regulates the trimer-hexamer equilibrium of hCE1 and allows each hCE1 monomer to bind two narcotic molecules simultaneously. The bioscavenger properties of hCE1 can likely be used to treat both narcotic overdose and chemical weapon exposure.
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(as it appears on PubMed at http://www.pubmed.gov), where 12679808 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12679808}}
==About this Structure==
==About this Structure==
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[[Category: Heroin]]
[[Category: Heroin]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:49:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:36:02 2008''

Revision as of 09:36, 29 July 2008

Image:1mx9.png

Template:STRUCTURE 1mx9

Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue

Template:ABSTRACT PUBMED 12679808

About this Structure

1MX9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme., Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR, Nat Struct Biol. 2003 May;10(5):349-56. PMID:12679808

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