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2d6f

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[[Image:2d6f.gif|left|200px]]
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{{STRUCTURE_2d6f| PDB=2d6f | SCENE= }}
{{STRUCTURE_2d6f| PDB=2d6f | SCENE= }}
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'''Crystal structure of Glu-tRNA(Gln) amidotransferase in the complex with tRNA(Gln)'''
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===Crystal structure of Glu-tRNA(Gln) amidotransferase in the complex with tRNA(Gln)===
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==Overview==
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Glutaminyl-transfer RNA (Gln-tRNA(Gln)) in archaea is synthesized in a pretranslational amidation of misacylated Glu-tRNA(Gln) by the heterodimeric Glu-tRNA(Gln) amidotransferase GatDE. Here we report the crystal structure of the Methanothermobacter thermautotrophicus GatDE complexed to tRNA(Gln) at 3.15 angstroms resolution. Biochemical analysis of GatDE and of tRNA(Gln) mutants characterized the catalytic centers for the enzyme's three reactions (glutaminase, kinase, and amidotransferase activity). A 40 angstrom-long channel for ammonia transport connects the active sites in GatD and GatE. tRNA(Gln) recognition by indirect readout based on shape complementarity of the D loop suggests an early anticodon-independent RNA-based mechanism for adding glutamine to the genetic code.
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(as it appears on PubMed at http://www.pubmed.gov), where 16809540 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16809540}}
==About this Structure==
==About this Structure==
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[[Category: Ligase]]
[[Category: Ligase]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:47:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:37:30 2008''

Revision as of 09:37, 29 July 2008

Image:2d6f.png

Template:STRUCTURE 2d6f

Crystal structure of Glu-tRNA(Gln) amidotransferase in the complex with tRNA(Gln)

Template:ABSTRACT PUBMED 16809540

About this Structure

2D6F is a Protein complex structure of sequences from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

Structural basis of RNA-dependent recruitment of glutamine to the genetic code., Oshikane H, Sheppard K, Fukai S, Nakamura Y, Ishitani R, Numata T, Sherrer RL, Feng L, Schmitt E, Panvert M, Blanquet S, Mechulam Y, Soll D, Nureki O, Science. 2006 Jun 30;312(5782):1950-4. PMID:16809540

Page seeded by OCA on Tue Jul 29 12:37:30 2008

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