1va4

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{{STRUCTURE_1va4| PDB=1va4 | SCENE= }}
{{STRUCTURE_1va4| PDB=1va4 | SCENE= }}
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'''Pseudomonas fluorescens aryl esterase'''
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===Pseudomonas fluorescens aryl esterase===
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==Overview==
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The structure of PFE, an aryl esterase from Pseudomonas fluorescens, has been solved to a resolution of 1.8 A by X-ray diffraction and shows a characteristic alpha/beta-hydrolase fold. In addition to catalyzing the hydrolysis of esters in vitro, PFE also shows low bromoperoxidase activity. PFE shows highest structural similarity, including the active-site environment, to a family of non-heme bacterial haloperoxidases, with an r.m.s. deviation in 271 C(alpha) atoms between PFE and its five closest structural neighbors averaging 0.8 A. PFE has far less similarity (r.m.s. deviation in 218 C(alpha) atoms of 5.0 A) to P. fluorescens carboxyl esterase. PFE favors activated esters with small acyl groups, such as phenyl acetate. The X-ray structure of PFE reveals a significantly occluded active site. In addition, several residues, including Trp28 and Met95, limit the size of the acyl-binding pocket, explaining its preference for small acyl groups.
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(as it appears on PubMed at http://www.pubmed.gov), where 15213385 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15213385}}
==About this Structure==
==About this Structure==
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[[Category: Esterase]]
[[Category: Esterase]]
[[Category: Non-cofactor dependent haloperoxidase]]
[[Category: Non-cofactor dependent haloperoxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:48:04 2008''

Revision as of 09:48, 29 July 2008

Image:1va4.png

Template:STRUCTURE 1va4

Pseudomonas fluorescens aryl esterase

Template:ABSTRACT PUBMED 15213385

About this Structure

1VA4 is a Single protein structure of sequence from Pseudomonas fluorescens. Full crystallographic information is available from OCA.

Reference

Structure of an aryl esterase from Pseudomonas fluorescens., Cheeseman JD, Tocilj A, Park S, Schrag JD, Kazlauskas RJ, Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1237-43. Epub 2004, Jun 22. PMID:15213385

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