1n2r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1n2r.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1n2r.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1n2r| PDB=1n2r | SCENE= }}
{{STRUCTURE_1n2r| PDB=1n2r | SCENE= }}
-
'''A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition.'''
+
===A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition.===
-
==Overview==
+
<!--
-
HLA-B*4402 and B*4403 are naturally occurring MHC class I alleles that are both found at a high frequency in all human populations, and yet they only differ by one residue on the alpha2 helix (B*4402 Asp156--&gt;B*4403 Leu156). CTLs discriminate between HLA-B*4402 and B*4403, and these allotypes stimulate strong mutual allogeneic responses reflecting their known barrier to hemopoeitic stem cell transplantation. Although HLA-B*4402 and B*4403 share &gt;95% of their peptide repertoire, B*4403 presents more unique peptides than B*4402, consistent with the stronger T cell alloreactivity observed toward B*4403 compared with B*4402. Crystal structures of B*4402 and B*4403 show how the polymorphism at position 156 is completely buried and yet alters both the peptide and the heavy chain conformation, relaxing ligand selection by B*4403 compared with B*4402. Thus, the polymorphism between HLA-B*4402 and B*4403 modifies both peptide repertoire and T cell recognition, and is reflected in the paradoxically powerful alloreactivity that occurs across this "minimal" mismatch. The findings suggest that these closely related class I genes are maintained in diverse human populations through their differential impact on the selection of peptide ligands and the T cell repertoire.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12939341}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12939341 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12939341}}
==Disease==
==Disease==
Line 42: Line 46:
[[Category: Mhc i]]
[[Category: Mhc i]]
[[Category: Signal]]
[[Category: Signal]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:01:10 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:50:47 2008''

Revision as of 09:50, 29 July 2008

Image:1n2r.png

Template:STRUCTURE 1n2r

Contents

A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition.

Template:ABSTRACT PUBMED 12939341

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1N2R is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition., Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J, J Exp Med. 2003 Sep 1;198(5):679-91. Epub 2003 Aug 25. PMID:12939341

Page seeded by OCA on Tue Jul 29 12:50:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n2r"
Personal tools