This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3bug

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3bug.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3bug.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3bug| PDB=3bug | SCENE= }}
{{STRUCTURE_3bug| PDB=3bug | SCENE= }}
-
'''BACE-1 complexed with compound 3'''
+
===BACE-1 complexed with compound 3===
-
==Overview==
+
<!--
-
Fragment screening revealed that tyramine binds to the active site of the Alzheimer's disease drug target BACE-1. Hit expansion by selection of compounds from the Roche compound library identified tyramine derivatives with improved binding affinities as monitored by surface plasmon resonance. X-ray structures show that the amine of the tyramine fragment hydrogen-bonds to the catalytic water molecule. Structure-guided ligand design led to the synthesis of further low molecular weight compounds that are starting points for chemical leads.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18226904}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18226904 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18226904}}
==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:06:57 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:10:02 2008''

Revision as of 10:10, 29 July 2008

Image:3bug.png

Template:STRUCTURE 3bug

BACE-1 complexed with compound 3

Template:ABSTRACT PUBMED 18226904

About this Structure

3BUG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Tyramine fragment binding to BACE-1., Kuglstatter A, Stahl M, Peters JU, Huber W, Stihle M, Schlatter D, Benz J, Ruf A, Roth D, Enderle T, Hennig M, Bioorg Med Chem Lett. 2008 Feb 15;18(4):1304-7. Epub 2008 Jan 11. PMID:18226904

Page seeded by OCA on Tue Jul 29 13:10:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bug"
Personal tools