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1pp1

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[[Image:1pp1.gif|left|200px]]
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{{STRUCTURE_1pp1| PDB=1pp1 | SCENE= }}
{{STRUCTURE_1pp1| PDB=1pp1 | SCENE= }}
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'''Crystal structure of the Borna Disease Virus Nucleoprotein'''
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===Crystal structure of the Borna Disease Virus Nucleoprotein===
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==Overview==
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Borna disease virus (BDV) causes an infection of the central nervous system in a wide range of vertebrates, which can fatally progress to an immune-mediated disease, called Borna disease. BDV is a member of the Mononegavirales, which also includes the highly infectious measles and Ebola viruses. The viral nucleoproteins are central to transcription, replication, and packaging of the RNA genome. We present the X-ray structure of the BDV nucleoprotein determined at 1.76 A resolution. The structure reveals a novel fold, organized into two distinct domains, and an assembly into a planar homotetramer. Surface potential calculations strongly support an RNA binding model with the RNA wrapping around the outside of the tetramer, although a positively charged central channel in the tetramer could fit single-stranded RNA in an alternative binding mode. This first structure of an RNA virus nucleoprotein provides a paradigmatic model for RNA packaging and replication of single-stranded RNA viruses.
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(as it appears on PubMed at http://www.pubmed.gov), where 14527390 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14527390}}
==About this Structure==
==About this Structure==
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[[Category: Rudolph, M G.]]
[[Category: Rudolph, M G.]]
[[Category: Rna virus nucleoprotein tetramer]]
[[Category: Rna virus nucleoprotein tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:19:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:17:00 2008''

Revision as of 10:17, 29 July 2008

Image:1pp1.png

Template:STRUCTURE 1pp1

Crystal structure of the Borna Disease Virus Nucleoprotein

Template:ABSTRACT PUBMED 14527390

About this Structure

1PP1 is a Single protein structure of sequence from Borna disease virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the borna disease virus nucleoprotein., Rudolph MG, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R, Structure. 2003 Oct;11(10):1219-26. PMID:14527390

Page seeded by OCA on Tue Jul 29 13:17:00 2008

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