2bz6

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[[Image:2bz6.gif|left|200px]]
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{{Seed}}
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[[Image:2bz6.png|left|200px]]
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{{STRUCTURE_2bz6| PDB=2bz6 | SCENE= }}
{{STRUCTURE_2bz6| PDB=2bz6 | SCENE= }}
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'''ORALLY AVAILABLE FACTOR7A INHIBITOR'''
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===ORALLY AVAILABLE FACTOR7A INHIBITOR===
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==Overview==
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The discovery of a highly potent and selective tissue factor/factor VIIa inhibitor is described. Upon oral administration of its double prodrug in the guinea pig, a dose-dependent antithrombotic effect is observed in an established model of arterial thrombosis without prolonging bleeding time. The pharmacodynamic properties of this selective inhibitor are compared to the behaviour of a mixed factor VIIa/factor Xa inhibitor.
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The line below this paragraph, {{ABSTRACT_PUBMED_16621574}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16621574 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16621574}}
==About this Structure==
==About this Structure==
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[[Category: Wessel, H P.]]
[[Category: Wessel, H P.]]
[[Category: Serine protease,coagulation,enzyme complex,hydrolase]]
[[Category: Serine protease,coagulation,enzyme complex,hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:00:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:24:37 2008''

Revision as of 10:24, 29 July 2008

Image:2bz6.png

Template:STRUCTURE 2bz6

ORALLY AVAILABLE FACTOR7A INHIBITOR

Template:ABSTRACT PUBMED 16621574

About this Structure

2BZ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity., Groebke Zbinden K, Banner DW, Hilpert K, Himber J, Lave T, Riederer MA, Stahl M, Tschopp TB, Obst-Sander U, Bioorg Med Chem. 2006 Aug 1;14(15):5357-69. Epub 2006 Apr 18. PMID:16621574

Page seeded by OCA on Tue Jul 29 13:24:37 2008

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