2boo

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[[Image:2boo.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2boo| PDB=2boo | SCENE= }}
{{STRUCTURE_2boo| PDB=2boo | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF URACIL-DNA N-GLYCOSYLASE (UNG) FROM DEINOCOCCUS RADIODURANS.'''
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===THE CRYSTAL STRUCTURE OF URACIL-DNA N-GLYCOSYLASE (UNG) FROM DEINOCOCCUS RADIODURANS.===
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==Overview==
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Uracil-DNA glycosylases are DNA-repair enzymes that catalyse the removal of promutagenic uracil from single- and double-stranded DNA, thereby initiating the base-excision repair (BER) pathway. Uracil in DNA can occur by mis-incorporation of dUMP in place of dTMP during DNA synthesis or by deamination of cytosine, resulting in U-A or U-G mispairs. The radiation-resistant bacterium Deinococcus radiodurans has an elevated number of uracil-DNA glycosylases compared with most other organisms. The crystal structure of dr0689 (uracil-DNA N-glycosylase), which has been shown to be the major contributor to the removal of mis-incorporated uracil bases in crude cell extracts of D. radiodurans, is reported.
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The line below this paragraph, {{ABSTRACT_PUBMED_16041069}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16041069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16041069}}
==About this Structure==
==About this Structure==
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[[Category: Ung]]
[[Category: Ung]]
[[Category: Uracil-dna glycosylase]]
[[Category: Uracil-dna glycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:35:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:37:18 2008''

Revision as of 10:37, 29 July 2008

Image:2boo.png

Template:STRUCTURE 2boo

THE CRYSTAL STRUCTURE OF URACIL-DNA N-GLYCOSYLASE (UNG) FROM DEINOCOCCUS RADIODURANS.

Template:ABSTRACT PUBMED 16041069

About this Structure

2BOO is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans., Leiros I, Moe E, Smalas AO, McSweeney S, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1049-56. Epub 2005, Jul 20. PMID:16041069

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