1q8h

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{{Seed}}
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{{STRUCTURE_1q8h| PDB=1q8h | SCENE= }}
{{STRUCTURE_1q8h| PDB=1q8h | SCENE= }}
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'''Crystal structure of porcine osteocalcin'''
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===Crystal structure of porcine osteocalcin===
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==Overview==
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Osteocalcin is the most abundant noncollagenous protein in bone, and its concentration in serum is closely linked to bone metabolism and serves as a biological marker for the clinical assessment of bone disease. Although its precise mechanism of action is unclear, osteocalcin influences bone mineralization, in part through its ability to bind with high affinity to the mineral component of bone, hydroxyapatite. In addition to binding to hydroxyapatite, osteocalcin functions in cell signalling and the recruitment of osteoclasts and osteoblasts, which have active roles in bone resorption and deposition, respectively. Here we present the X-ray crystal structure of porcine osteocalcin at 2.0 A resolution, which reveals a negatively charged protein surface that coordinates five calcium ions in a spatial orientation that is complementary to calcium ions in a hydroxyapatite crystal lattice. On the basis of our findings, we propose a model of osteocalcin binding to hydroxyapatite and draw parallels with other proteins that engage crystal lattices.
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(as it appears on PubMed at http://www.pubmed.gov), where 14586470 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14586470}}
==About this Structure==
==About this Structure==
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[[Category: Hydroxyapatite crystal surface binding protein]]
[[Category: Hydroxyapatite crystal surface binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:59:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:40:50 2008''

Revision as of 10:40, 29 July 2008

Image:1q8h.png

Template:STRUCTURE 1q8h

Crystal structure of porcine osteocalcin

Template:ABSTRACT PUBMED 14586470

About this Structure

1Q8H is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Bone recognition mechanism of porcine osteocalcin from crystal structure., Hoang QQ, Sicheri F, Howard AJ, Yang DS, Nature. 2003 Oct 30;425(6961):977-80. PMID:14586470

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