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1uei

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[[Image:1uei.gif|left|200px]]
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{{STRUCTURE_1uei| PDB=1uei | SCENE= }}
{{STRUCTURE_1uei| PDB=1uei | SCENE= }}
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'''Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, UTP'''
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===Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, UTP===
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==Overview==
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Uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine and cytidine and activates pharmacological ribonucleoside analogs. Here we present the crystal structures of human UCK alone and in complexes with a substrate, cytidine, a feedback inhibitor, CTP or UTP, and with phosphorylation products, CMP and ADP, respectively. Free UCK takes an alpha/beta mononucleotide binding fold and exists as a homotetramer with 222 symmetry. Upon inhibitor binding, one loop region was loosened, causing the UCK tetramer to be distorted. Upon cytidine binding, a large induced fit was observed at the uridine/cytidine binding site, which endows UCK with a strict specificity for pyrimidine ribonucleosides. The first UCK structure provided the structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase, which give clues for the design of novel antitumor and antiviral ribonucleoside analogs that inhibit RNA synthesis.
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The line below this paragraph, {{ABSTRACT_PUBMED_15130468}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15130468 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15130468}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase., Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F, Structure. 2004 May;12(5):751-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15130468 15130468]
Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase., Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F, Structure. 2004 May;12(5):751-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15130468 15130468]
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Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2., Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F, Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1477-8. Epub 2003, Jul 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12876357 12876357]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Suzuki, N N.]]
[[Category: Suzuki, N N.]]
[[Category: Alpha/beta mononucleotide-binding hold]]
[[Category: Alpha/beta mononucleotide-binding hold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:42:16 2008''

Revision as of 10:42, 29 July 2008

Image:1uei.png

Template:STRUCTURE 1uei

Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, UTP

Template:ABSTRACT PUBMED 15130468

About this Structure

1UEI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase., Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F, Structure. 2004 May;12(5):751-64. PMID:15130468

Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2., Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F, Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1477-8. Epub 2003, Jul 23. PMID:12876357

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