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1pk6

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{{STRUCTURE_1pk6| PDB=1pk6 | SCENE= }}
{{STRUCTURE_1pk6| PDB=1pk6 | SCENE= }}
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'''Globular Head of the Complement System Protein C1q'''
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===Globular Head of the Complement System Protein C1q===
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==Overview==
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C1q is a versatile recognition protein that binds to an amazing variety of immune and non-immune ligands and triggers activation of the classical pathway of complement. The crystal structure of the C1q globular domain responsible for its recognition properties has now been solved and refined to 1.9 A of resolution. The structure reveals a compact, almost spherical heterotrimeric assembly held together mainly by non-polar interactions, with a Ca2+ ion bound at the top. The heterotrimeric assembly of the C1q globular domain appears to be a key factor of the versatile recognition properties of this protein. Plausible three-dimensional models of the C1q globular domain in complex with two of its physiological ligands, C-reactive protein and IgG, are proposed, highlighting two of the possible recognition modes of C1q. The C1q/human IgG1 model suggests a critical role for the hinge region of IgG and for the relative orientation of its Fab domain in C1q binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 12960167 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12960167}}
==About this Structure==
==About this Structure==
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[[Category: Immunology]]
[[Category: Immunology]]
[[Category: Jellyroll]]
[[Category: Jellyroll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:10:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:42:44 2008''

Revision as of 10:42, 29 July 2008

Image:1pk6.png

Template:STRUCTURE 1pk6

Globular Head of the Complement System Protein C1q

Template:ABSTRACT PUBMED 12960167

About this Structure

1PK6 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties., Gaboriaud C, Juanhuix J, Gruez A, Lacroix M, Darnault C, Pignol D, Verger D, Fontecilla-Camps JC, Arlaud GJ, J Biol Chem. 2003 Nov 21;278(47):46974-82. Epub 2003 Sep 5. PMID:12960167

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