2baf

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[[Image:2baf.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2baf| PDB=2baf | SCENE= }}
{{STRUCTURE_2baf| PDB=2baf | SCENE= }}
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'''Bovine Fibrinogen alpha-C Domain'''
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===Bovine Fibrinogen alpha-C Domain===
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==Overview==
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The NMR solution structure of the bovine fibrinogen alphaC-domain fragment, including residues Aalpha374-538, reveals a type-I' beta-hairpin, restricted at the base by a C423-C453 disulfide linkage and a short turn preceding C423. Although both faces of the hairpin are formed mainly by hydrophilic residues, one of them is uncharged while the other has a characteristic pattern of charged residues which are highly conserved among vertebrate species. Chemical shift indexing and relaxation data indicate the presence of a collapsed hydrophobic region next to the hairpin that includes approximately 30 residues with slower concerted motion and higher content of nonpolar residues and, according to a previous study (Tsurupa, G., Tsonev, L., and Medved, L. (2002) Biochemistry 41, 6449-6459), may cooperate with the hairpin to form a compact cooperative unit (domain). Structure and relaxation data show that the region between C423 and C453 is populated by both random coil and beta-structure, suggesting that the cooperative structure in the isolated alphaC-domain is intrinsically unstable. This observation is in agreement with a very low energy of stabilization of the Aalpha374-538 fragment determined in unfolding experiments. The low stability of the alphaC-domain suggests a possible explanation for the previously observed intra- and intermolecular interactions of these domains in fibrinogen and fibrin.
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(as it appears on PubMed at http://www.pubmed.gov), where 16475814 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16475814}}
==About this Structure==
==About this Structure==
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2BAF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAF OCA].
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2BAF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAF OCA].
==Reference==
==Reference==
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[[Category: Beta hairpin]]
[[Category: Beta hairpin]]
[[Category: Fibrinogen]]
[[Category: Fibrinogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:02:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:44:37 2008''

Revision as of 10:44, 29 July 2008

Image:2baf.png

Template:STRUCTURE 2baf

Bovine Fibrinogen alpha-C Domain

Template:ABSTRACT PUBMED 16475814

About this Structure

2BAF is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Identification of an ordered compact structure within the recombinant bovine fibrinogen alphaC-domain fragment by NMR., Burton RA, Tsurupa G, Medved L, Tjandra N, Biochemistry. 2006 Feb 21;45(7):2257-66. PMID:16475814

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