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1r6v

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{{STRUCTURE_1r6v| PDB=1r6v | SCENE= }}
{{STRUCTURE_1r6v| PDB=1r6v | SCENE= }}
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'''Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin'''
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===Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin===
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==Overview==
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Structure-forming fibrous proteins like keratins, gelatins and collagens are degraded only by a few proteases as their tight packing limits access to the potential cleavage sites. To understand the keratin degradation in detail, we describe the first crystal structure of a keratin-degrading enzyme (keratinase), fervidolysin, from Fervidobacterium pennivorans as an immature form with propeptide (PD)-bound. The 1.7A resolution crystal structure shows that the protease is composed of four domains: a catalytic domain (CD), two beta-sandwich domains (SDs), and the PD domain. A structural alignment shows a distant relationship between the PD-CD substructure of fervidolysin and pro-subtilisin E. Tight binding of PD to the remaining part of the protease is mediated by hydrogen bonds along the domain surfaces and around the active cleft, and by the clamps to SD1 and SD2. The crystal structure of this multi-domain protein fervidolysin provides insights into proenzyme activation and the role of non-catalytic domains, suggesting a functional relationship to the fibronectin (FN)-like domains of the human promatrix metalloprotease-2 (proMMP-2) that degrades the fibrous polymeric substrate gelatin.
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(as it appears on PubMed at http://www.pubmed.gov), where 14687574 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14687574}}
==About this Structure==
==About this Structure==
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[[Category: Sandwich domain]]
[[Category: Sandwich domain]]
[[Category: Subtilisin]]
[[Category: Subtilisin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:09:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:10:36 2008''

Revision as of 11:10, 29 July 2008

Image:1r6v.png

Template:STRUCTURE 1r6v

Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin

Template:ABSTRACT PUBMED 14687574

About this Structure

1R6V is a Single protein structure of sequence from Fervidobacterium pennivorans. Full crystallographic information is available from OCA.

Reference

Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin., Kim JS, Kluskens LD, de Vos WM, Huber R, van der Oost J, J Mol Biol. 2004 Jan 16;335(3):787-97. PMID:14687574

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