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1qy5

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{{STRUCTURE_1qy5| PDB=1qy5 | SCENE= }}
{{STRUCTURE_1qy5| PDB=1qy5 | SCENE= }}
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'''Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with the specific ligand NECA'''
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===Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with the specific ligand NECA===
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==Overview==
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GRP94, the endoplasmic reticulum (ER) paralog of the chaperone Hsp90, plays an essential role in the structural maturation or secretion of a subset of proteins destined for transport to the cell surface, such as the Toll-like receptors 2 and 4, and IgG, respectively. GRP94 differs from cytoplasmic Hsp90 by exhibiting very weak ATP binding and hydrolysis activity. GRP94 also binds selectively to a series of substituted adenosine analogs. The high resolution crystal structures at 1.75-2.1 A of the N-terminal and adjacent charged domains of GRP94 in complex with N-ethylcarboxamidoadenosine, radicicol, and 2-chlorodideoxyadenosine reveals a structural mechanism for ligand discrimination among hsp90 family members. The structures also identify a putative subdomain that may act as a ligand-responsive switch. The residues of the charged region fold into a disordered loop whose termini are ordered and continue the twisted beta sheet that forms the structural core of the N-domain. This continuation of the beta sheet past the charged domain suggests a structural basis for the association of the N-terminal and middle domains of the full-length chaperone.
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(as it appears on PubMed at http://www.pubmed.gov), where 12970348 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12970348}}
==About this Structure==
==About this Structure==
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[[Category: Hsp90]]
[[Category: Hsp90]]
[[Category: Neca]]
[[Category: Neca]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:50:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:44:42 2008''

Revision as of 11:44, 29 July 2008

Image:1qy5.png

Template:STRUCTURE 1qy5

Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with the specific ligand NECA

Template:ABSTRACT PUBMED 12970348

About this Structure

1QY5 is a Single protein structure of sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

Reference

Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation., Soldano KL, Jivan A, Nicchitta CV, Gewirth DT, J Biol Chem. 2003 Nov 28;278(48):48330-8. Epub 2003 Sep 11. PMID:12970348

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