1uk0

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{{STRUCTURE_1uk0| PDB=1uk0 | SCENE= }}
{{STRUCTURE_1uk0| PDB=1uk0 | SCENE= }}
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'''Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor'''
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===Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor===
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==Overview==
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The crystal structure of human recombinant poly(ADP-ribose) polymerase (PARP) complexed with a potent inhibitor, FR257517, was solved at 3.0 A resolution. The fluorophenyl part of the inhibitor induces an amazing conformational change in the active site of PARP by motion of the side chain of the amino acid, Arg878, which forms the bottom of the active site. Consequently, a corn-shaped hydrophobic subsite, which consists of the side chains of Leu769, Ile879, Pro881, and the methylene chain of Arg878, newly emerges from the well-known active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 14706823 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14706823}}
==About this Structure==
==About this Structure==
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[[Category: Kinoshita, T.]]
[[Category: Kinoshita, T.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:19:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:44:53 2008''

Revision as of 11:44, 29 July 2008

Image:1uk0.png

Template:STRUCTURE 1uk0

Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor

Template:ABSTRACT PUBMED 14706823

About this Structure

1UK0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase., Kinoshita T, Nakanishi I, Warizaya M, Iwashita A, Kido Y, Hattori K, Fujii T, FEBS Lett. 2004 Jan 2;556(1-3):43-6. PMID:14706823

Page seeded by OCA on Tue Jul 29 14:44:53 2008

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