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1u6g

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{{STRUCTURE_1u6g| PDB=1u6g | SCENE= }}
{{STRUCTURE_1u6g| PDB=1u6g | SCENE= }}
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'''Crystal Structure of The Cand1-Cul1-Roc1 Complex'''
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===Crystal Structure of The Cand1-Cul1-Roc1 Complex===
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==Overview==
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The SCF ubiquitin ligase complex regulates diverse cellular functions by ubiquitinating numerous protein substrates. Cand1, a 120 kDa HEAT repeat protein, forms a tight complex with the Cul1-Roc1 SCF catalytic core, inhibiting the assembly of the multisubunit E3 complex. The crystal structure of the Cand1-Cul1-Roc1 complex shows that Cand1 adopts a highly sinuous superhelical structure, clamping around the elongated SCF scaffold protein Cul1. At one end, a Cand1 beta hairpin protrusion partially occupies the adaptor binding site on Cul1, inhibiting its interactions with the Skp1 adaptor and the substrate-recruiting F box protein subunits. At the other end, two Cand1 HEAT repeats pack against a conserved Cul1 surface cleft and bury a Cul1 lysine residue, whose modification by the ubiquitin-like protein, Nedd8, is able to block Cand1-Cul1 association. Together with biochemical evidence, these structural results elucidate the mechanisms by which Cand1 and Nedd8 regulate the assembly-disassembly cycles of SCF and other cullin-dependent E3 complexes.
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{{ABSTRACT_PUBMED_15537541}}
==About this Structure==
==About this Structure==
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[[Category: Heat repeat]]
[[Category: Heat repeat]]
[[Category: Ring finger]]
[[Category: Ring finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:49:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:51:47 2008''

Revision as of 11:51, 29 July 2008

Image:1u6g.png

Template:STRUCTURE 1u6g

Crystal Structure of The Cand1-Cul1-Roc1 Complex

Template:ABSTRACT PUBMED 15537541

About this Structure

1U6G is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases., Goldenberg SJ, Cascio TC, Shumway SD, Garbutt KC, Liu J, Xiong Y, Zheng N, Cell. 2004 Nov 12;119(4):517-28. PMID:15537541

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