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1xfh

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{{STRUCTURE_1xfh| PDB=1xfh | SCENE= }}
{{STRUCTURE_1xfh| PDB=1xfh | SCENE= }}
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'''Structure of glutamate transporter homolog from Pyrococcus horikoshii'''
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===Structure of glutamate transporter homolog from Pyrococcus horikoshii===
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==Overview==
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Glutamate transporters are integral membrane proteins that catalyse the concentrative uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion gradients. In the central nervous system glutamate transporters are essential for normal development and function, and are implicated in stroke, epilepsy and neurodegenerative diseases. Here we present the crystal structure of a eukaryotic glutamate transporter homologue from Pyrococcus horikoshii. The transporter is a bowl-shaped trimer with a solvent-filled extracellular basin extending halfway across the membrane bilayer. At the bottom of the basin are three independent binding sites, each cradled by two helical hairpins, reaching from opposite sides of the membrane. We propose that transport of glutamate is achieved by movements of the hairpins that allow alternating access to either side of the membrane.
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{{ABSTRACT_PUBMED_15483603}}
==About this Structure==
==About this Structure==
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[[Category: Yernool, D.]]
[[Category: Yernool, D.]]
[[Category: Trimeric helical transmembrane protein]]
[[Category: Trimeric helical transmembrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:57:02 2008''

Revision as of 11:57, 29 July 2008

Image:1xfh.png

Template:STRUCTURE 1xfh

Structure of glutamate transporter homolog from Pyrococcus horikoshii

Template:ABSTRACT PUBMED 15483603

About this Structure

1XFH is a Single protein structure of sequence from Pyrococcus horikoshii ot3. Full crystallographic information is available from OCA.

Reference

Structure of a glutamate transporter homologue from Pyrococcus horikoshii., Yernool D, Boudker O, Jin Y, Gouaux E, Nature. 2004 Oct 14;431(7010):811-8. PMID:15483603

Page seeded by OCA on Tue Jul 29 14:57:02 2008

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