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1ovl

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[[Image:1ovl.gif|left|200px]]
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{{STRUCTURE_1ovl| PDB=1ovl | SCENE= }}
{{STRUCTURE_1ovl| PDB=1ovl | SCENE= }}
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'''Crystal Structure of Nurr1 LBD'''
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===Crystal Structure of Nurr1 LBD===
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==Overview==
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Members of the nuclear receptor (NR) superfamily of transcription factors modulate gene transcription in response to small lipophilic molecules. Transcriptional activity is regulated by ligands binding to the carboxy-terminal ligand-binding domains (LBDs) of cognate NRs. A subgroup of NRs referred to as 'orphan receptors' lack identified ligands, however, raising issues about the function of their LBDs. Here we report the crystal structure of the LBD of the orphan receptor Nurr1 at 2.2 A resolution. The Nurr1 LBD adopts a canonical protein fold resembling that of agonist-bound, transcriptionally active LBDs in NRs, but the structure has two distinctive features. First, the Nurr1 LBD contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. Second, Nurr1 lacks a 'classical' binding site for coactivators. Despite these differences, the Nurr1 LBD can be regulated in mammalian cells. Notably, transcriptional activity is correlated with the Nurr1 LBD adopting a more stable conformation. Our findings highlight a unique structural class of NRs and define a model for ligand-independent NR function.
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The line below this paragraph, {{ABSTRACT_PUBMED_12774125}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12774125 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12774125}}
==About this Structure==
==About this Structure==
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[[Category: Lbd]]
[[Category: Lbd]]
[[Category: Nuur1]]
[[Category: Nuur1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:19:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:02:48 2008''

Revision as of 12:02, 29 July 2008

Image:1ovl.png

Template:STRUCTURE 1ovl

Crystal Structure of Nurr1 LBD

Template:ABSTRACT PUBMED 12774125

About this Structure

1OVL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors., Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T, Nature. 2003 May 29;423(6939):555-60. PMID:12774125

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