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2rgu

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[[Image:2rgu.jpg|left|200px]]
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{{STRUCTURE_2rgu| PDB=2rgu | SCENE= }}
{{STRUCTURE_2rgu| PDB=2rgu | SCENE= }}
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'''Crystal structure of complex of human DPP4 and inhibitor'''
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===Crystal structure of complex of human DPP4 and inhibitor===
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==Overview==
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A new chemical class of potent DPP-4 inhibitors structurally derived from the xanthine scaffold for the treatment of type 2 diabetes has been discovered and evaluated. Systematic structural variations have led to 1 (BI 1356), a highly potent, selective, long-acting, and orally active DPP-4 inhibitor that shows considerable blood glucose lowering in different animal species. 1 is currently undergoing clinical phase IIb trials and holds the potential for once-daily treatment of type 2 diabetics.
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(as it appears on PubMed at http://www.pubmed.gov), where 18052023 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18052023}}
==About this Structure==
==About this Structure==
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[[Category: Signal-anchor]]
[[Category: Signal-anchor]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:53:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:07:11 2008''

Revision as of 12:07, 29 July 2008

Image:2rgu.png

Template:STRUCTURE 2rgu

Crystal structure of complex of human DPP4 and inhibitor

Template:ABSTRACT PUBMED 18052023

About this Structure

2RGU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin -2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes., Eckhardt M, Langkopf E, Mark M, Tadayyon M, Thomas L, Nar H, Pfrengle W, Guth B, Lotz R, Sieger P, Fuchs H, Himmelsbach F, J Med Chem. 2007 Dec 27;50(26):6450-3. Epub 2007 Dec 1. PMID:18052023

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