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1p0r

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[[Image:1p0r.jpg|left|200px]]
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{{STRUCTURE_1p0r| PDB=1p0r | SCENE= }}
{{STRUCTURE_1p0r| PDB=1p0r | SCENE= }}
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'''Solution Structure of UBL5 a human Ubiquitin-Like Protein'''
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===Solution Structure of UBL5 a human Ubiquitin-Like Protein===
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==Overview==
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UBL5 is a widely expressed human protein that is strongly conserved across phylogeny. Orthologs of UBL5 occur in every eukaryotic genome characterized to date. The yeast ortholog of UBL5, HUB1, was reported to be a ubiquitin-like protein modifier important for modulation of protein function. However, unlike ubiquitin and all other ubiquitin-like modifiers, UBL5 and its yeast ortholog HUB1 both contain a C-terminal di-tyrosine motif followed by a single variable residue instead of the characteristic di-glycine found in all other ubiquitin-like modifiers. Here we describe the three-dimensional structure of UBL5 determined by NMR. The overall structure of the protein was found to be very similar to ubiquitin despite the low approximately 25% residue similarity. The signature C-terminal di-tyrosine residues in UBL5 are involved in the final beta sheet of the protein. This is very different to the di-glycine motif found in ubiquitin, which extends beyond the final beta sheet. In addition, we have confirmed an earlier report of an interaction between UBL5 and the cyclin-like kinase, CLK4, which we have determined is specific and does not extend to other cyclin-like kinase family members.
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The line below this paragraph, {{ABSTRACT_PUBMED_12824502}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12824502 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12824502}}
==About this Structure==
==About this Structure==
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1P0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0R OCA].
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1P0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0R OCA].
==Reference==
==Reference==
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[[Category: Reilly, R M.]]
[[Category: Reilly, R M.]]
[[Category: Ubiquitin-like fold]]
[[Category: Ubiquitin-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:32:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:08:35 2008''

Revision as of 12:08, 29 July 2008

Image:1p0r.png

Template:STRUCTURE 1p0r

Solution Structure of UBL5 a human Ubiquitin-Like Protein

Template:ABSTRACT PUBMED 12824502

About this Structure

1P0R is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural analysis of UBL5, a novel ubiquitin-like modifier., McNally T, Huang Q, Janis RS, Liu Z, Olejniczak ET, Reilly RM, Protein Sci. 2003 Jul;12(7):1562-6. PMID:12824502

Page seeded by OCA on Tue Jul 29 15:08:35 2008

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