2d7d

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[[Image:2d7d.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2d7d| PDB=2d7d | SCENE= }}
{{STRUCTURE_2d7d| PDB=2d7d | SCENE= }}
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'''Structural insights into the cryptic DNA dependent ATP-ase activity of UvrB'''
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===Structural insights into the cryptic DNA dependent ATP-ase activity of UvrB===
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==Overview==
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The UvrABC pathway is a ubiquitously occurring mechanism targeted towards the repair of bulky base damage. Key to this process is UvrB, a DNA-dependent limited helicase that acts as a lesion recognition element whilst part of a tracking complex involving UvrA, and as a DNA-binding platform required for the presentation of damage to UvrC for subsequent processing. We have been able to determine the structure of a ternary complex involving UvrB* (a C-terminal truncation of full-length UvrB), a polythymine trinucleotide and ADP. This structure has highlighted the roles of key conserved residues in DNA binding distinct from those of the beta-hairpin, where most of the attention in previous studies has been focussed. We are also the first to report the structural basis underlying conformational re-modelling of the beta-hairpin that is absolutely required for DNA binding and how this event results in an ATPase primed for catalysis. Our data provide the first insights at the molecular level into the transformation of UvrB into an active helicase.
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(as it appears on PubMed at http://www.pubmed.gov), where 16426634 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16426634}}
==About this Structure==
==About this Structure==
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[[Category: Helicase]]
[[Category: Helicase]]
[[Category: Protein-dna-adp ternary complex]]
[[Category: Protein-dna-adp ternary complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:48:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:27:53 2008''

Revision as of 12:27, 29 July 2008

Image:2d7d.png

Template:STRUCTURE 2d7d

Structural insights into the cryptic DNA dependent ATP-ase activity of UvrB

Template:ABSTRACT PUBMED 16426634

About this Structure

2D7D is a Protein complex structure of sequences from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structural insights into the cryptic DNA-dependent ATPase activity of UvrB., Eryilmaz J, Ceschini S, Ryan J, Geddes S, Waters TR, Barrett TE, J Mol Biol. 2006 Mar 17;357(1):62-72. Epub 2006 Jan 6. PMID:16426634

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