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2aj1

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[[Image:2aj1.gif|left|200px]]
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{{STRUCTURE_2aj1| PDB=2aj1 | SCENE= }}
{{STRUCTURE_2aj1| PDB=2aj1 | SCENE= }}
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'''Solution structure of apoCadA'''
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===Solution structure of apoCadA===
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==Overview==
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In bacteria, P1-type ATPases are responsible for resistance to di- and monovalent toxic heavy metals by taking them out of the cell. These ATPases have a cytoplasmic N terminus comprising metal binding domains defined by a betaalphabetabetaalphabeta fold and a CXXC metal binding motif. To check how the structural properties of the metal binding site in the N terminus can influence the metal specificity of the ATPase, the first structure of a Cd(II)-ATPase N terminus was determined by NMR and its coordination sphere was investigated by X-ray absorption spectroscopy. A novel metal binding environment was found, comprising the two conserved Cys residues of the metal binding motif and a Glu in loop 5. A bioinformatic search identifies an ensemble of highly homologous sequences presumably with the same function. Another group of highly homologous sequences is found which can be referred to as zinc-detoxifying P1-type ATPases with the metal binding pattern DCXXC in the N terminus. Because no carboxylate groups participate in Cu(I) or Ag(I) binding sites, we suggest that the acidic residue plays a key role in the coordination properties of divalent cations, hence conferring a function to the N terminus in the metal specificity of the ATPase.
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(as it appears on PubMed at http://www.pubmed.gov), where 16388822 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16388822}}
==About this Structure==
==About this Structure==
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2AJ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJ1 OCA].
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2AJ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJ1 OCA].
==Reference==
==Reference==
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[[Category: Ferrodoxin-like fold]]
[[Category: Ferrodoxin-like fold]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:06:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:34:53 2008''

Revision as of 12:34, 29 July 2008

Image:2aj1.png

Template:STRUCTURE 2aj1

Solution structure of apoCadA

Template:ABSTRACT PUBMED 16388822

About this Structure

2AJ1 is a Single protein structure of sequence from Listeria monocytogenes. Full experimental information is available from OCA.

Reference

Structural basis for metal binding specificity: the N-terminal cadmium binding domain of the P1-type ATPase CadA., Banci L, Bertini I, Ciofi-Baffoni S, Su XC, Miras R, Bal N, Mintz E, Catty P, Shokes JE, Scott RA, J Mol Biol. 2006 Feb 24;356(3):638-50. Epub 2005 Dec 5. PMID:16388822

Page seeded by OCA on Tue Jul 29 15:34:53 2008

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