2df5

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[[Image:2df5.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2df5| PDB=2df5 | SCENE= }}
{{STRUCTURE_2df5| PDB=2df5 | SCENE= }}
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'''Crystal Structure of Pf-PCP(1-204)-C'''
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===Crystal Structure of Pf-PCP(1-204)-C===
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==Overview==
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Certain sequences, known as chameleon sequences, take both alpha- and beta-conformations in natural proteins. We demonstrate that a wild chameleon sequence fused to the C-terminal alpha-helix or beta-sheet in foreign stable proteins from hyperthermophiles forms the same conformation as the host secondary structure. However, no secondary structural formation is observed when the sequence is attached to the outside of the secondary structure. These results indicate that this sequence inherently possesses an ability to make either alpha- or beta-conformation, depending on the sequentially neighboring secondary structure if little other nonlocal interaction occurs. Thus, chameleon sequences take on a satellite state through contagion by the power of a secondary structure. We propose this "conformational contagion" as a new nonlocal determinant factor in protein structure and misfolding related to protein conformational diseases.
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(as it appears on PubMed at http://www.pubmed.gov), where 17510955 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17510955}}
==About this Structure==
==About this Structure==
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[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrrolidone carboxyl peptidase]]
[[Category: Pyrrolidone carboxyl peptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:18:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:42:47 2008''

Revision as of 12:42, 29 July 2008

Image:2df5.png

Template:STRUCTURE 2df5

Crystal Structure of Pf-PCP(1-204)-C

Template:ABSTRACT PUBMED 17510955

About this Structure

2DF5 is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.

Reference

Conformational contagion in a protein: structural properties of a chameleon sequence., Takano K, Katagiri Y, Mukaiyama A, Chon H, Matsumura H, Koga Y, Kanaya S, Proteins. 2007 Aug 15;68(3):617-25. PMID:17510955

Page seeded by OCA on Tue Jul 29 15:42:47 2008

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