2dq7

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{{STRUCTURE_2dq7| PDB=2dq7 | SCENE= }}
{{STRUCTURE_2dq7| PDB=2dq7 | SCENE= }}
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'''Crystal Structure of Fyn kinase domain complexed with staurosporine'''
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===Crystal Structure of Fyn kinase domain complexed with staurosporine===
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==Overview==
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The tyrosine kinase Fyn is a member of the Src kinase family. Besides the role of Fyn in T cell signal transduction in concert with Lck, its excess activity in the brain is involved with conditions such as Alzheimer's and Parkinson's diseases. Therefore, inhibition of Fyn kinase may help counteract these nervous system disorders. Here, we solved the crystal structure of the human Fyn kinase domain complexed with staurosporine, a potent kinase inhibitor, at 2.8 A resolution. Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes. The small structural differences in the staurosporine-binding and/or -unbinding region among the three kinase domains may help obtaining the selective inhibitors against the respective kinases.
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(as it appears on PubMed at http://www.pubmed.gov), where 16782058 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16782058}}
==About this Structure==
==About this Structure==
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[[Category: Src family]]
[[Category: Src family]]
[[Category: Staurosporine]]
[[Category: Staurosporine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:57:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:58:13 2008''

Revision as of 12:58, 29 July 2008

Image:2dq7.png

Template:STRUCTURE 2dq7

Crystal Structure of Fyn kinase domain complexed with staurosporine

Template:ABSTRACT PUBMED 16782058

About this Structure

2DQ7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human Fyn kinase domain complexed with staurosporine., Kinoshita T, Matsubara M, Ishiguro H, Okita K, Tada T, Biochem Biophys Res Commun. 2006 Aug 4;346(3):840-4. Epub 2006 Jun 13. PMID:16782058

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