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1puc

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{{STRUCTURE_1puc| PDB=1puc | SCENE= }}
{{STRUCTURE_1puc| PDB=1puc | SCENE= }}
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'''P13SUC1 IN A STRAND-EXCHANGED DIMER'''
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===P13SUC1 IN A STRAND-EXCHANGED DIMER===
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==Overview==
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BACKGROUND. p13(suc1) from fission yeast is a member of the CDC28 kinase specific (CKS) class of cell-cycle control proteins, that includes CKS1 from budding yeast and the human homologues CksHs1 and CksHs2. p13(suc1) participates in the regulation of p34(cdc2), a cyclin-dependent kinase controlling the G1-S and the G2-M transitions of the cell cycle. The CKS proteins are believed to exert their regulatory activity by binding to the kinase, in which case their function may be governed by their conformation or oligomerization state. Previously determined X-ray structures of p13(suc1), CksHs1 and CksHs2 show that these proteins share a common fold but adopt different oligomeric states. Monomeric forms of p13(suc1) and CksHs1 have been solved. In addition, CksHs2 and p13(suc1) have been observed by X-ray crystallography in assemblies of strand-exchanged dimers. Analysis of various assemblies of the CKS proteins, as found in different crystal forms, should help to clarify their role in cell-cycle control. RESULTS. We report the X-ray crystal structure of p13(suc1) to 1.95 A resolution in space group C2221. It is present in the crystals as a strand-exchanged dimer. The overall monomeric fold is preserved in each lobe of the dimer but a single beta-strand (Ile94-Asp102) is exchanged between the central beta-sheets of each molecule. CONCLUSIONS. Strand exchange, which has been observed for p13(suc1) in two different space groups, and for CksHs2, is now confirmed to be an intrinsic feature of the CKS family. A switch between levels of assembly may serve to coordinate the function of the CKS proteins in cell-cycle control.
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(as it appears on PubMed at http://www.pubmed.gov), where 8805536 is the PubMed ID number.
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==About this Structure==
==About this Structure==
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[[Category: Domain swapping]]
[[Category: Domain swapping]]
[[Category: Strand-exchanged dimer]]
[[Category: Strand-exchanged dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:29:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:05:58 2008''

Revision as of 13:06, 29 July 2008

Image:1puc.png

Template:STRUCTURE 1puc

P13SUC1 IN A STRAND-EXCHANGED DIMER

Template:ABSTRACT PUBMED 8805536

About this Structure

1PUC is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Crystal structure of the yeast cell-cycle control protein, p13suc1, in a strand-exchanged dimer., Khazanovich N, Bateman K, Chernaia M, Michalak M, James M, Structure. 1996 Mar 15;4(3):299-309. PMID:8805536

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