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1xvy

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[[Image:1xvy.gif|left|200px]]
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{{STRUCTURE_1xvy| PDB=1xvy | SCENE= }}
{{STRUCTURE_1xvy| PDB=1xvy | SCENE= }}
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'''Crystal Structure of iron-free Serratia marcescens SfuA'''
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===Crystal Structure of iron-free Serratia marcescens SfuA===
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==Overview==
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The uptake of the element iron is vital for the survival of most organisms. Numerous pathogenic Gram-negative bacteria utilize a periplasm-to-cytosol ATP-binding cassette transport pathway to transport this essential atom in to the cell. In this study, we investigated the Yersinia enterocolitica (YfuA) and Serratia marcescens (SfuA) iron-binding periplasmic proteins. We have determined the 1.8-angstroms structures of iron-loaded (YfuA) and iron-free (SfuA) forms of this class of proteins. Although the sequence of these proteins varies considerably from the other members of the transferrin structural superfamily, they adopt the same three-dimensional fold. The iron-loaded YfuA structure illustrates the unique nature of this new class of proteins in that they are able to octahedrally coordinate the ferric ion in the absence of a bound anion. The iron-free SfuA structure contains a bound citrate anion in the iron-binding cleft that tethers the N- and C-terminal domains of the apo protein and stabilizes the partially open structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_15576371}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15576371 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15576371}}
==About this Structure==
==About this Structure==
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[[Category: Tari, L W.]]
[[Category: Tari, L W.]]
[[Category: Periplasmic iron binding protein]]
[[Category: Periplasmic iron binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:34:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:14:49 2008''

Revision as of 13:14, 29 July 2008

Image:1xvy.png

Template:STRUCTURE 1xvy

Crystal Structure of iron-free Serratia marcescens SfuA

Template:ABSTRACT PUBMED 15576371

About this Structure

1XVY is a Single protein structure of sequence from Yersinia enterocolitica. Full crystallographic information is available from OCA.

Reference

Novel anion-independent iron coordination by members of a third class of bacterial periplasmic ferric ion-binding proteins., Shouldice SR, McRee DE, Dougan DR, Tari LW, Schryvers AB, J Biol Chem. 2005 Feb 18;280(7):5820-7. Epub 2004 Dec 2. PMID:15576371

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