1uuj

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[[Image:1uuj.gif|left|200px]]
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{{STRUCTURE_1uuj| PDB=1uuj | SCENE= }}
{{STRUCTURE_1uuj| PDB=1uuj | SCENE= }}
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'''N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)'''
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===N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)===
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==Overview==
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Mutations in the Lis1 gene result in lissencephaly (smooth brain), a debilitating developmental syndrome caused by the impaired ability of postmitotic neurons to migrate to their correct destination in the cerebral cortex. Sequence similarities suggest that the LIS1 protein contains a C-terminal seven-blade beta-propeller domain, while the structure of the N-terminal fragment includes the LisH (Lis-homology) motif, a pattern found in over 100 eukaryotic proteins with a hitherto unknown function. We present the 1.75 A resolution crystal structure of the N-terminal domain of mouse LIS1, and we show that the LisH motif is a novel, thermodynamically very stable dimerization domain. The structure explains the molecular basis of a low severity form of lissencephaly.
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(as it appears on PubMed at http://www.pubmed.gov), where 15274919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15274919}}
==About this Structure==
==About this Structure==
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[[Category: Neurogenesis]]
[[Category: Neurogenesis]]
[[Category: Platelet-activating factor acetylhydrolase]]
[[Category: Platelet-activating factor acetylhydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:42:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:25:35 2008''

Revision as of 13:25, 29 July 2008

Image:1uuj.png

Template:STRUCTURE 1uuj

N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)

Template:ABSTRACT PUBMED 15274919

About this Structure

1UUJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications., Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS, Structure. 2004 Jun;12(6):987-98. PMID:15274919

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