This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1uuj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1uuj.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1uuj.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1uuj| PDB=1uuj | SCENE= }}
{{STRUCTURE_1uuj| PDB=1uuj | SCENE= }}
-
'''N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)'''
+
===N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)===
-
==Overview==
+
<!--
-
Mutations in the Lis1 gene result in lissencephaly (smooth brain), a debilitating developmental syndrome caused by the impaired ability of postmitotic neurons to migrate to their correct destination in the cerebral cortex. Sequence similarities suggest that the LIS1 protein contains a C-terminal seven-blade beta-propeller domain, while the structure of the N-terminal fragment includes the LisH (Lis-homology) motif, a pattern found in over 100 eukaryotic proteins with a hitherto unknown function. We present the 1.75 A resolution crystal structure of the N-terminal domain of mouse LIS1, and we show that the LisH motif is a novel, thermodynamically very stable dimerization domain. The structure explains the molecular basis of a low severity form of lissencephaly.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15274919}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15274919 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15274919}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Neurogenesis]]
[[Category: Neurogenesis]]
[[Category: Platelet-activating factor acetylhydrolase]]
[[Category: Platelet-activating factor acetylhydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:42:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:25:35 2008''

Revision as of 13:25, 29 July 2008

Image:1uuj.png

Template:STRUCTURE 1uuj

N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)

Template:ABSTRACT PUBMED 15274919

About this Structure

1UUJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications., Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS, Structure. 2004 Jun;12(6):987-98. PMID:15274919

Page seeded by OCA on Tue Jul 29 16:25:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uuj"
Personal tools