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1tnp

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[[Image:1tnp.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1tnp| PDB=1tnp | SCENE= }}
{{STRUCTURE_1tnp| PDB=1tnp | SCENE= }}
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'''STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH'''
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===STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH===
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==Overview==
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Regulation of contraction in skeletal muscle occurs through calcium binding to the protein troponin C. The solution structures of the regulatory domain of apo and calcium-loaded troponin C have been determined by multinuclear, multidimensional nuclear magnetic resonance techniques. The structural transition in the regulatory domain of troponin C on calcium binding involves an opening of the structure through large changes in interhelical angles. This leads to the increased exposure of an extensive hydrophobic patch, an event that triggers skeletal muscle contraction.
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The line below this paragraph, {{ABSTRACT_PUBMED_7552750}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7552750 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7552750}}
==About this Structure==
==About this Structure==
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1TNP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TNP OCA].
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1TNP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TNP OCA].
==Reference==
==Reference==
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[[Category: Sykes, B D.]]
[[Category: Sykes, B D.]]
[[Category: Ef-hand]]
[[Category: Ef-hand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:09:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:29:41 2008''

Revision as of 13:29, 29 July 2008

Image:1tnp.png

Template:STRUCTURE 1tnp

STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH

Template:ABSTRACT PUBMED 7552750

About this Structure

1TNP is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Structures of the troponin C regulatory domains in the apo and calcium-saturated states., Gagne SM, Tsuda S, Li MX, Smillie LB, Sykes BD, Nat Struct Biol. 1995 Sep;2(9):784-9. PMID:7552750

Page seeded by OCA on Tue Jul 29 16:29:41 2008

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