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1z9c

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[[Image:1z9c.gif|left|200px]]
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{{STRUCTURE_1z9c| PDB=1z9c | SCENE= }}
{{STRUCTURE_1z9c| PDB=1z9c | SCENE= }}
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'''Crystal structure of OhrR bound to the ohrA promoter: Structure of MarR family protein with operator DNA'''
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===Crystal structure of OhrR bound to the ohrA promoter: Structure of MarR family protein with operator DNA===
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==Overview==
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The mechanisms by which Bacillus subtilis OhrR, a member of the MarR family of transcription regulators, binds the ohrA operator and is induced by oxidation of its lone cysteine residue by organic hydroperoxides to sulphenic acid are unknown. Here, we describe the crystal structures of reduced OhrR and an OhrR-ohrA operator complex. To bind DNA, OhrR employs a chimeric winged helix-turn-helix DNA binding motif, which is composed of extended eukaryotic-like wings, prokaryotic helix-turn-helix motifs, and helix-helix elements. The reactivity of the peroxide-sensing cysteine is not modulated by proximal basic residues but largely by the positive dipole of helix alpha1. Induction originates from the alleviation of intersubunit steric clash between the sulphenic acid moieties of the oxidized sensor cysteines and nearby tyrosines and methionines. The structure of the OhrR-ohrA operator complex reveals the DNA binding mechanism of the entire MarR family and suggests a common inducer binding pocket.
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The line below this paragraph, {{ABSTRACT_PUBMED_16209951}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16209951 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16209951}}
==About this Structure==
==About this Structure==
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[[Category: Ohrr]]
[[Category: Ohrr]]
[[Category: Winged hth protein]]
[[Category: Winged hth protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:20:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:39:42 2008''

Revision as of 13:39, 29 July 2008

Image:1z9c.png

Template:STRUCTURE 1z9c

Crystal structure of OhrR bound to the ohrA promoter: Structure of MarR family protein with operator DNA

Template:ABSTRACT PUBMED 16209951

About this Structure

1Z9C is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family., Hong M, Fuangthong M, Helmann JD, Brennan RG, Mol Cell. 2005 Oct 7;20(1):131-41. PMID:16209951

Page seeded by OCA on Tue Jul 29 16:39:42 2008

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