User:Wayne Decatur/Suppression of RNA Silencing by Viruses

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Andrew Z. Fire and Craig C. Mello shared [http://nobelprize.org/nobel_prizes/medicine/laureates/2006/ the 2006 Nobel Prize in Medicine or Physiology] for their discovery of [http://en.wikipedia.org/wiki/RNA_interference RNA interference] - gene silencing by double-stranded RNA.<br>
Andrew Z. Fire and Craig C. Mello shared [http://nobelprize.org/nobel_prizes/medicine/laureates/2006/ the 2006 Nobel Prize in Medicine or Physiology] for their discovery of [http://en.wikipedia.org/wiki/RNA_interference RNA interference] - gene silencing by double-stranded RNA.<br>
RNA interference (RNAi) (also known as post-transcriptional gene silencing (PTGS) or RNA silencing) is an evolutionarily conserved cellular response to the presence of double-stranded (ds) RNA that functions as a gene inactivation system in many eukaryotes and relies on tiny RNAs as the targeting molecules. One function of RNA silencing is to act in surveillance against molecular parasites, such as viruses, several of which rely on double-stranded RNA for replication. Viruses have developed mechanisms to counteract RNAi by providing proteins that sequester the tiny [http://en.wikipedia.org/wiki/Small_interfering_RNA silencing RNAs (siRNAs)] targeted against viral RNAs.<br>
RNA interference (RNAi) (also known as post-transcriptional gene silencing (PTGS) or RNA silencing) is an evolutionarily conserved cellular response to the presence of double-stranded (ds) RNA that functions as a gene inactivation system in many eukaryotes and relies on tiny RNAs as the targeting molecules. One function of RNA silencing is to act in surveillance against molecular parasites, such as viruses, several of which rely on double-stranded RNA for replication. Viruses have developed mechanisms to counteract RNAi by providing proteins that sequester the tiny [http://en.wikipedia.org/wiki/Small_interfering_RNA silencing RNAs (siRNAs)] targeted against viral RNAs.<br>
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For further introduction to RNA interference, see [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=rna%20interference&rid=mboc4.section.1363#1399 the pertinent section] in [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4 Molecular Biology of the Cell by Alberts et al.].
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For a general introduction to RNA interference, see [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=rna%20interference&rid=mboc4.section.1363#1399 the pertinent section] in [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4 Molecular Biology of the Cell by Alberts et al.] or [www.hhmi.org/biointeractive/rna/rnai/index.htmlthe Howard Hughes Medical Institute interactive online resource on the RNAi mechanism and overview of key scientific findings].
Several structures have provided insight into the basis for the molecular interactions involved in suppression of gene silencing (RNAi) by plant and animal viruses.
Several structures have provided insight into the basis for the molecular interactions involved in suppression of gene silencing (RNAi) by plant and animal viruses.

Revision as of 16:54, 2 November 2008


Background

Andrew Z. Fire and Craig C. Mello shared the 2006 Nobel Prize in Medicine or Physiology for their discovery of RNA interference - gene silencing by double-stranded RNA.
RNA interference (RNAi) (also known as post-transcriptional gene silencing (PTGS) or RNA silencing) is an evolutionarily conserved cellular response to the presence of double-stranded (ds) RNA that functions as a gene inactivation system in many eukaryotes and relies on tiny RNAs as the targeting molecules. One function of RNA silencing is to act in surveillance against molecular parasites, such as viruses, several of which rely on double-stranded RNA for replication. Viruses have developed mechanisms to counteract RNAi by providing proteins that sequester the tiny silencing RNAs (siRNAs) targeted against viral RNAs.
For a general introduction to RNA interference, see the pertinent section in Molecular Biology of the Cell by Alberts et al. or [www.hhmi.org/biointeractive/rna/rnai/index.htmlthe Howard Hughes Medical Institute interactive online resource on the RNAi mechanism and overview of key scientific findings].

Several structures have provided insight into the basis for the molecular interactions involved in suppression of gene silencing (RNAi) by plant and animal viruses.

Related Structures and Topics

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Wayne Decatur

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