Sandbox2qc8
From Proteopedia
(Difference between revisions)
(→Glutamine Synthetase: Secondary structures) |
(→Glutamine Synthetase: Secondary structures) |
||
| Line 14: | Line 14: | ||
=Glutamine Synthetase: Secondary structures= | =Glutamine Synthetase: Secondary structures= | ||
| - | Glutamine synthetase is composed of 12 <scene name='Sandbox2qc8/Identical_subunits/1'>identical subunits</scene>. | + | Glutamine synthetase is composed of 12 <scene name='Sandbox2qc8/Identical_subunits/1'>identical subunits</scene>. Each subunit is composed of 15 <scene name='Sandbox2qc8/Subunit_alpha/1'>alpha helices</scene> and 12 |
| + | <scene name='Sandbox2qc8/Subunit_beta/1'>beta sheets</scene>, as well as a <scene name='Sandbox2qc8/Subunit_ligand/1'>ligand complex</scene>. | ||
Each subunit has an exposed NH2 terminus and buried COOH terminus as part of a helical thong. <ref>Yamashita, M., et al.,Refined Atomic Model of Glutamine Synthetase at 3.5A Resolution, The Journal of Biological Chemistry, 1989, 17681-17690.</ref> | Each subunit has an exposed NH2 terminus and buried COOH terminus as part of a helical thong. <ref>Yamashita, M., et al.,Refined Atomic Model of Glutamine Synthetase at 3.5A Resolution, The Journal of Biological Chemistry, 1989, 17681-17690.</ref> | ||
| - | |||
| - | Each subunit is composed predominantly of 12 <scene name='Sandbox2qc8/Subunit_alpha/1'>alpha helices</scene> and 12 | ||
| - | <scene name='Sandbox2qc8/Subunit_beta/1'>beta sheets</scene>, as well as a <scene name='Sandbox2qc8/Subunit_ligand/1'>ligand complex</scene>. | ||
The beta sheets are arranged into two separate partial beta barrels, one of which encompasses the ligand complex. | The beta sheets are arranged into two separate partial beta barrels, one of which encompasses the ligand complex. | ||
Revision as of 17:12, 17 December 2008
| |||||||||
| 2qc8, resolution 2.60Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||||
| Gene: | GLUL, GLNS (Homo sapiens) | ||||||||
| Activity: | Glutamate--ammonia ligase, with EC number 6.3.1.2 | ||||||||
| Related: | 2ojw | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Exercises
Click here to view .
Click here to view .
Click here to view .
Click here to view .
Glutamine Synthetase: Secondary structures
Glutamine synthetase is composed of 12 . Each subunit is composed of 15 and 12 , as well as a .
Each subunit has an exposed NH2 terminus and buried COOH terminus as part of a helical thong. [1]
The beta sheets are arranged into two separate partial beta barrels, one of which encompasses the ligand complex.
The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.[2]
The ligands present are Cl, Mn, Adenosine Diphosphate, and L-Methionine-S-Sulfoximine Phosphate.
