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3d0a

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3d0a.jpg|left|200px]]
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The entry 3d0a is ON HOLD until Paper Publication
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{{STRUCTURE_3d0a| PDB=3d0a | SCENE= }}
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Authors: Suad, O., Rozenberg, H., Diskin-Posner, Y., Kessler, N., W Shimon, L.J., Frolow, F., Brosh, R., Liran, A., Rotter, V., Shakked, Z.
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===Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA===
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Description: p53 (6)
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 12:12:28 2008''
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(as it appears on PubMed at http://www.pubmed.gov), where 18996393 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18996393}}
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==Disease==
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Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Hepatocellular carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Histiocytoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Li-Fraumeni syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Multiple malignancy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Nasopharyngeal carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Osteosarcoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Thyroid carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]]
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==About this Structure==
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3D0A is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0A OCA].
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==Reference==
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<ref group="xtra">PMID:18996393</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Rozenberg, H.]]
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[[Category: Shakked, Z.]]
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[[Category: Suad, O.]]
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[[Category: Acetylation]]
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[[Category: Activator]]
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[[Category: Alternative splicing]]
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[[Category: Anti-oncogene]]
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[[Category: Apoptosis]]
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[[Category: Cell cycle]]
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[[Category: Covalent protein-rna linkage]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Dna target]]
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[[Category: Dna-binding]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Glycoprotein]]
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[[Category: Host-virus interaction]]
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[[Category: Li-fraumeni syndrome]]
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[[Category: Loop-sheet-helix motif]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Mutant protein]]
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[[Category: Nucleus]]
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[[Category: P53]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription/dna complex]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:44:44 2009''

Revision as of 08:44, 21 January 2009

Image:3d0a.jpg

Template:STRUCTURE 3d0a

Contents

Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA

Template:ABSTRACT PUBMED 18996393

Disease

Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[191170], Breast cancer OMIM:[191170], Colorectal cancer OMIM:[191170], Hepatocellular carcinoma OMIM:[191170], Histiocytoma OMIM:[191170], Li-Fraumeni syndrome OMIM:[191170], Multiple malignancy syndrome OMIM:[191170], Nasopharyngeal carcinoma OMIM:[191170], Osteosarcoma OMIM:[191170], Pancreatic cancer OMIM:[191170], Thyroid carcinoma OMIM:[191170]

About this Structure

3D0A is a 8 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Suad O, Rozenberg H, Brosh R, Diskin-Posner Y, Kessler N, Shimon LJ, Frolow F, Liran A, Rotter V, Shakked Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. J Mol Biol. 2009 Jan 9;385(1):249-65. Epub 2008 Oct 30. PMID:18996393 doi:10.1016/j.jmb.2008.10.063

Page seeded by OCA on Wed Jan 21 10:44:44 2009

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