2f9u

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==About this Structure==
==About this Structure==
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2F9U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9U OCA].
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2F9U is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9U OCA].
==Reference==
==Reference==
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Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid., Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. Epub 2006 Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16413182 16413182]
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<ref group="xtra">PMID:16413182</ref><ref group="xtra">PMID:8861917</ref><ref group="xtra">PMID:16112862</ref><ref group="xtra">PMID:16078825</ref><ref group="xtra">PMID:16211639</ref><ref group="xtra">PMID:15501035</ref><references group="xtra"/>
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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8861917 8861917]
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+
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Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency., Bogen S, Saksena AK, Arasappan A, Gu H, Njoroge FG, Girijavallabhan V, Pichardo J, Butkiewicz N, Prongay A, Madison V, Bioorg Med Chem Lett. 2005 Oct 15;15(20):4515-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16112862 16112862]
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-
 
+
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Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design., Venkatraman S, Njoroge FG, Girijavallabhan VM, Madison VS, Yao NH, Prongay AJ, Butkiewicz N, Pichardo J, J Med Chem. 2005 Aug 11;48(16):5088-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16078825 16078825]
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-
 
+
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Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity., Chen KX, Njoroge FG, Vibulbhan B, Prongay A, Pichardo J, Madison V, Buevich A, Chan TM, Angew Chem Int Ed Engl. 2005 Nov 4;44(43):7024-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16211639 16211639]
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-
 
+
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Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex., Arasappan A, Njoroge FG, Parekh TN, Yang X, Pichardo J, Butkiewicz N, Prongay A, Yao N, Girijavallabhan V, Bioorg Med Chem Lett. 2004 Dec 6;14(23):5751-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15501035 15501035]
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[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
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[[Category: Protein complex]]
 
[[Category: Butkiewicz, N.]]
[[Category: Butkiewicz, N.]]
[[Category: Girijavallabhan, V.]]
[[Category: Girijavallabhan, V.]]
Line 48: Line 37:
[[Category: Ns3 protease]]
[[Category: Ns3 protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:58:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:53:03 2009''

Revision as of 09:53, 16 February 2009

Image:2f9u.png

Template:STRUCTURE 2f9u

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane

Template:ABSTRACT PUBMED 16413182

About this Structure

2F9U is a 4 chains structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J. Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. Epub 2006 Jan 18. PMID:16413182 doi:10.1016/j.bmcl.2005.12.046
  • Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell. 1996 Oct 18;87(2):343-55. PMID:8861917
  • Bogen S, Saksena AK, Arasappan A, Gu H, Njoroge FG, Girijavallabhan V, Pichardo J, Butkiewicz N, Prongay A, Madison V. Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4515-9. PMID:16112862 doi:10.1016/j.bmcl.2005.07.009
  • Venkatraman S, Njoroge FG, Girijavallabhan VM, Madison VS, Yao NH, Prongay AJ, Butkiewicz N, Pichardo J. Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design. J Med Chem. 2005 Aug 11;48(16):5088-91. PMID:16078825 doi:10.1021/jm0489556
  • Chen KX, Njoroge FG, Vibulbhan B, Prongay A, Pichardo J, Madison V, Buevich A, Chan TM. Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity. Angew Chem Int Ed Engl. 2005 Nov 4;44(43):7024-8. PMID:16211639 doi:10.1002/anie.200501553
  • Arasappan A, Njoroge FG, Parekh TN, Yang X, Pichardo J, Butkiewicz N, Prongay A, Yao N, Girijavallabhan V. Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5751-5. PMID:15501035 doi:10.1016/j.bmcl.2004.09.058

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