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Sandbox315
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| - | This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! | + | This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Juna Jovani |
==Macrophage Elastase== | ==Macrophage Elastase== | ||
| - | Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a <scene name='Sandbox315/1jk3_hydrophobic/1'>hydrophobic</scene> active-site cleft. | + | Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a <scene name='Sandbox315/1jk3_hydrophobic/1'>hydrophobic</scene> active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has two <scene name='Sandbox315/Beta_sheet/1'>beta sheets</scene> shown in purple. |
| - | Reference: | ||
| - | {{STRUCTURE_1jk3 | PDB=1jk3 | SCENE= }} | ||
| - | + | Reference[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-457CY1P-6G&_user=1516330&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000053443&_version=1&_urlVersion=0&_userid=1516330&md5=374e1e8bd2911c09295d019540f42bca] | |
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| + | |||
| + | {{STRUCTURE_1jk3 | PDB=1jk3 | SCENE= }} | ||
Current revision
This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Juna Jovani
Macrophage Elastase
Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has two shown in purple.
Reference[1]
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| 1jk3, resolution 1.09Å () | |||||||||
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| Ligands: | , , | ||||||||
| Activity: | Macrophage elastase, with EC number 3.4.24.65 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
