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| - | [[Image:2pmx.gif|left|200px]] | + | #REDIRECT [[3gft]] This PDB entry is obsolete and replaced by 3gft |
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| - | {{Structure
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| - | |PDB= 2pmx |SIZE=350|CAPTION= <scene name='initialview01'>2pmx</scene>, resolution 2.270Å
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| - | |SITE=
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| - | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene> and <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene>
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| - | |ACTIVITY=
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| - | |GENE= KRAS, KRAS2, RASK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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| - | }}
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| - | '''Human K-Ras in complex with a GTP analogue'''
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| - | ==Disease==
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| - | Known diseases associated with this structure: Bladder cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190070 190070]], Breast cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190070 190070]], Costello syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190070 190070]], Leukemia, acute myelogenous OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190070 190070]], Lung cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190070 190070]], Noonan syndrome 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190070 190070]], Pancreatic carcinoma, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190070 190070]], Stomach cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190070 190070]]
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| - | ==About this Structure==
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| - | 2PMX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PMX OCA].
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Single protein]]
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| - | [[Category: Arrowsmith, C H.]]
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| - | [[Category: Bochkarev, A.]]
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| - | [[Category: Edwards, A M.]]
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| - | [[Category: Park, H.]]
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| - | [[Category: SGC, Structural Genomics Consortium.]]
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| - | [[Category: Shen, L.]]
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| - | [[Category: Sundstrom, M.]]
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| - | [[Category: Tempel, W.]]
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| - | [[Category: Tong, Y.]]
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| - | [[Category: Weigelt, J.]]
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| - | [[Category: CIT]]
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| - | [[Category: GNP]]
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| - | [[Category: MG]]
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| - | [[Category: cancer]]
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| - | [[Category: gtp analogue]]
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| - | [[Category: mutation]]
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| - | [[Category: sgc]]
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| - | [[Category: small gtpase]]
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| - | [[Category: structural genomics consortium]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:15:01 2008''
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