Rebecca Martin/Sandbox1

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	IgA1		IgA1
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Revision as of 13:58, 22 April 2009

Contents 1 Introduction 2 General Structure 3 IgA1 and IgA2 4 Secretory Component and Polyimmunoglobulin receptor 5 Insights into Function 6 Evolution 7 Implications in Science and Medicine 8 Limitations of the Current Studies 9 Questions for the Future 10 Links 10.1 IgA 10.2 Receptors 10.3 For Comparison 11 References

Introduction

IgA1

Template:STRUCTURE 3cm9

General Structure

• Antibody Structure
• Dimeric Structure

• Secretory Component

IgA1 and IgA2

spinqualitylabelsall models IgA2 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models IgA1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Secretory Component and Polyimmunoglobulin receptor

spinqualitylabelsall models This is the secretory component. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Insights into Function

Evolution

Implications in Science and Medicine

Limitations of the Current Studies

Questions for the Future

Links

IgA

• Model of human IgA1 determined by solution scattering, curve-fitting, and homology modeling 1iga
• Model of human IgA2 determined by solution scattering, curve fitting and homology modelling 1r70
• Crystal structure of human FcaRI bound to IgA1-Fc 1ow0
• Solution structure of human dimeric immunoglobulin A 2qtj
• Solution structure of human secretory IgA1 3chn
• Solution Structure of Human SIgA2 3cm9
• Solution structure of human secretory component 2ocw

Receptors

• Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR 1XED
• Crystal structure of human FcaRI 10vz
• Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 2qej

For Comparison

• IgM: Solution structure of human Immunoglobulin M 2rcj
• IgG:
• IgD:
• IgE:

References