C-di-GMP
From Proteopedia
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<applet load='2v0n' scene='C-di-GMP/C-di-gmp/1' size='400' frame='true' align='right' caption='cyclic di-GMP, as found in complex with the diguanylate cyclase PleD [[2v0n]]' /> | <applet load='2v0n' scene='C-di-GMP/C-di-gmp/1' size='400' frame='true' align='right' caption='cyclic di-GMP, as found in complex with the diguanylate cyclase PleD [[2v0n]]' /> | ||
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Revision as of 10:12, 15 July 2009
Cyclic di-GMP, (bis-(3'-5') cyclic diguanylic acid)
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C-di-GMP is a second messenger that mediates the regulation of cell-surface associated traits in bacteria.
is a cyclic dinucleotide with a 12-membered macro-cycle composed of the the phosphate and ribose moieties. It tends to associate to form with intercalated, stacked bases.
Several protein structures involved in c-di-GMP signaling have been determined (reviewed in User:Tilman_Schirmer/Sandbox_200).
References
Reviews:
- Egli M, Gessner RV, Williams LD, Quigley GJ, van der Marel GA, van Boom JH, Rich A, Frederick CA. Atomic-resolution structure of the cellulose synthase regulator cyclic diguanylic acid. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3235-9. PMID:2158107
- Guan Y, Gao YG, Liaw YC, Robinson H, Wang AH. Molecular structure of cyclic diguanylic acid at 1 A resolution of two crystal forms: self-association, interactions with metal ion/planar dyes and modeling studies. J Biomol Struct Dyn. 1993 Oct;11(2):253-76. PMID:8286055
