C-Myc
From Proteopedia
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{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }} | {{STRUCTURE_c-Myc PDB=2a93 | SCENE= }} | ||
| - | The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription. | + | The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription]. |
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | ||
Revision as of 20:18, 15 July 2009
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Template:STRUCTURE c-Myc PDB=2a93
The c-Myc oncogene encodes a transcription factor, c-Myc, which is involved in the regulation of the cell cycle. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription. Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.
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Michal Harel, Hillary Sigale, Kim Smith, David Canner, Joel L. Sussman, Alexander Berchansky
