1dy8
From Proteopedia
(New page: 200px<br /> <applet load="1dy8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dy8, resolution 2.4Å" /> '''INHIBITION OF THE HE...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1DY8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Hepatitis_c_virus_(isolate_1) Hepatitis c virus (isolate 1)]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DY8 OCA]]. | + | 1DY8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Hepatitis_c_virus_(isolate_1) Hepatitis c virus (isolate 1)]]. Structure known Active Sites: INA and INB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DY8 OCA]]. |
==Reference== | ==Reference== | ||
| Line 29: | Line 29: | ||
[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:34:35 2007'' |
Revision as of 06:29, 30 October 2007
|
INHIBITION OF THE HEPATITIS C VIRUS NS3/4A PROTEASE. THE CRYSTAL STRUCTURES OF TWO PROTEASE-INHIBITOR COMPLEXES (INHIBITOR II)
Overview
The hepatitis C virus NS3 protein contains a serine protease domain with a, chymotrypsin-like fold, which is a target for development of therapeutics., We report the crystal structures of this domain complexed with NS4A, cofactor and with two potent, reversible covalent inhibitors spanning the, P1-P4 residues. Both inhibitors bind in an extended backbone conformation, forming an anti-parallel beta-sheet with one enzyme beta-strand. The P1, residue contributes most to the binding energy, whereas P2-P4 side chains, are partially solvent exposed. The structures do not show notable, rearrangements of the active site upon inhibitor binding. These results, are significant for the development of antivirals.
About this Structure
1DY8 is a [Single protein] structure of sequence from [Hepatitis c virus (isolate 1)]. Structure known Active Sites: INA and INB. Full crystallographic information is available from [OCA].
Reference
Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes., Di Marco S, Rizzi M, Volpari C, Walsh MA, Narjes F, Colarusso S, De Francesco R, Matassa VG, Sollazzo M, J Biol Chem. 2000 Mar 10;275(10):7152-7. PMID:10702283
Page seeded by OCA on Tue Oct 30 08:34:35 2007
