1vpi
From Proteopedia
(New page: 200px<br /> <applet load="1vpi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vpi, resolution 1.76Å" /> '''PHOSPHOLIPASE A2 IN...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1VPI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vipera_ammodytes Vipera ammodytes]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VPI OCA]]. | + | 1VPI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vipera_ammodytes Vipera ammodytes]]. Structure known Active Site: RS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VPI OCA]]. |
==Reference== | ==Reference== | ||
| Line 22: | Line 22: | ||
[[Category: x-ray structure]] | [[Category: x-ray structure]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:34:47 2007'' |
Revision as of 06:30, 30 October 2007
|
PHOSPHOLIPASE A2 INHIBITOR FROM VIPOXIN
Overview
The high resolution crystal structure of a natural PLA2 inhibitor has been, determined by Patterson search methods. In the heterodimeric, neurotoxic, complex, vipoxin, isolated from the venom of Bulgarian viper, PLA2, inhibitor represents the non-toxic subunit. The model was refined to a, crystallographic R-factor of 15.5% for data between 6 and 1.76 A, resolution. The packing of the inhibitor in the crystal reveals close, contacts between the molecules, which are symmetry-related by the 2-fold, axes of the lattice. These pairs associate as a crystallographic dimer, stabilized by a set of interactions, including van der Waals contacts, between residues from symmetry-related pairs, denoted as the recognition, site and the recognition surface. Residues Ph3, Trp31 and Tyr119 represent, the ... [(full description)]
About this Structure
1VPI is a [Single protein] structure of sequence from [Vipera ammodytes]. Structure known Active Site: RS. Full crystallographic information is available from [OCA].
Reference
X-ray structure at 1.76 A resolution of a polypeptide phospholipase A2 inhibitor., Devedjiev Y, Popov A, Atanasov B, Bartunik HD, J Mol Biol. 1997 Feb 14;266(1):160-72. PMID:9054978
Page seeded by OCA on Tue Oct 30 08:34:47 2007
