1koa

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(New page: 200px<br /><applet load="1koa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1koa, resolution 3.3&Aring;" /> '''TWITCHIN KINASE FRAGM...)
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[[Image:1koa.gif|left|200px]]<br /><applet load="1koa" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1koa, resolution 3.3&Aring;" />
 
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'''TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS'''<br />
 
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==Overview==
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==TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS==
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The myosin-associated giant protein kinases twitchin and titin are, composed predominantly of fibronectin- and immunoglobulin-like modules. We, report the crystal structures of two autoinhibited twitchin kinase, fragments, one from Aplysia and a larger fragment from Caenorhabditis, elegans containing an additional C-terminal immunoglobulin-like domain., The structure of the longer fragment shows that the immunoglobulin domain, contacts the protein kinase domain on the opposite side from the catalytic, cleft, laterally exposing potential myosin binding residues. Together, the, structures reveal the cooperative interactions between the autoregulatory, region and the residues from the catalytic domain involved in protein, substrate binding, ATP binding, catalysis and the activation loop, and, explain the differences between the observed autoinhibitory mechanism and, the one found in the structure of calmodulin-dependent kinase I.
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<StructureSection load='1koa' size='340' side='right'caption='[[1koa]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1koa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KOA FirstGlance]. <br>
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1KOA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KOA OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1koa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1koa OCA], [https://pdbe.org/1koa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1koa RCSB], [https://www.ebi.ac.uk/pdbsum/1koa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1koa ProSAT]</span></td></tr>
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==Reference==
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</table>
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Giant protein kinases: domain interactions and structural basis of autoregulation., Kobe B, Heierhorst J, Feil SC, Parker MW, Benian GM, Weiss KR, Kemp BE, EMBO J. 1996 Dec 16;15(24):6810-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9003756 9003756]
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== Function ==
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[https://www.uniprot.org/uniprot/UNC22_CAEEL UNC22_CAEEL] Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces.<ref>PMID:7190524</ref> <ref>PMID:18390597</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/1koa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1koa ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Benian, G.M.]]
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[[Category: Benian GM]]
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[[Category: Feil, S.C.]]
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[[Category: Feil SC]]
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[[Category: Heierhorst, J.]]
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[[Category: Heierhorst J]]
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[[Category: Kemp, B.E.]]
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[[Category: Kemp BE]]
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[[Category: Kobe, B.]]
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[[Category: Kobe B]]
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[[Category: Parker, M.W.]]
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[[Category: Parker MW]]
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[[Category: Weiss, K.R.]]
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[[Category: Weiss KR]]
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[[Category: intrasteric regulation]]
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[[Category: kinase]]
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[[Category: twitchin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:39:17 2007''
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Current revision

TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS

PDB ID 1koa

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