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1kp7

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(New page: 200px<br /><applet load="1kp7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kp7" /> '''Conserved RNA Structure within the HCV IRES ...)
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[[Image:1kp7.gif|left|200px]]<br /><applet load="1kp7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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'''Conserved RNA Structure within the HCV IRES eIF3 Binding Site'''<br />
 
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==Overview==
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==Conserved RNA Structure within the HCV IRES eIF3 Binding Site==
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The hepatitis C virus (HCV) internal ribosome entry site (IRES) is, recognized specifically by the small ribosomal subunit and eukaryotic, initiation factor 3 (eIF3) before viral translation initiation. Using, extensive mutagenesis and structure probing analysis, we show that the, eIF3-binding domain of the HCV IRES contains an internal loop structure, (loop IIIb) and an adjacent mismatched helix that are important for, IRES-dependent initiation of translation. NMR studies reveal a unique, three-dimensional structure for this internal loop that is conserved, between viral isolates of varying primary sequence in this region. These, data indicate that internal loop IIIb may be an attractive target for, structure-based design of new antiviral agents.
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<StructureSection load='1kp7' size='340' side='right'caption='[[1kp7]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kp7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KP7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kp7 OCA], [https://pdbe.org/1kp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kp7 RCSB], [https://www.ebi.ac.uk/pdbsum/1kp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kp7 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The hepatitis C virus (HCV) internal ribosome entry site (IRES) is recognized specifically by the small ribosomal subunit and eukaryotic initiation factor 3 (eIF3) before viral translation initiation. Using extensive mutagenesis and structure probing analysis, we show that the eIF3-binding domain of the HCV IRES contains an internal loop structure (loop IIIb) and an adjacent mismatched helix that are important for IRES-dependent initiation of translation. NMR studies reveal a unique three-dimensional structure for this internal loop that is conserved between viral isolates of varying primary sequence in this region. These data indicate that internal loop IIIb may be an attractive target for structure-based design of new antiviral agents.
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==About this Structure==
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A conserved RNA structure within the HCV IRES eIF3-binding site.,Collier AJ, Gallego J, Klinck R, Cole PT, Harris SJ, Harrison GP, Aboul-Ela F, Varani G, Walker S Nat Struct Biol. 2002 May;9(5):375-80. PMID:11927954<ref>PMID:11927954</ref>
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1KP7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KP7 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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A conserved RNA structure within the HCV IRES eIF3-binding site., Collier AJ, Gallego J, Klinck R, Cole PT, Harris SJ, Harrison GP, Aboul-Ela F, Varani G, Walker S, Nat Struct Biol. 2002 May;9(5):375-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11927954 11927954]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1kp7" style="background-color:#fffaf0;"></div>
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[[Category: Aboul-ela, F.]]
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== References ==
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[[Category: Cole, P.T.]]
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<references/>
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[[Category: Collier, A.J.]]
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__TOC__
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[[Category: Gallego, J.]]
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</StructureSection>
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[[Category: Harris, S.J.]]
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[[Category: Large Structures]]
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[[Category: Harrison, G.P.]]
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[[Category: Aboul-ela F]]
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[[Category: Klinck, R.]]
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[[Category: Cole PT]]
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[[Category: Varani, G.]]
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[[Category: Collier AJ]]
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[[Category: Walker, S.]]
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[[Category: Gallego J]]
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[[Category: cytosine mismatch]]
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[[Category: Harris SJ]]
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[[Category: eif3]]
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[[Category: Harrison GP]]
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[[Category: hcv]]
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[[Category: Klinck R]]
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[[Category: internal loop]]
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[[Category: Varani G]]
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[[Category: ires]]
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[[Category: Walker S]]
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[[Category: s-turn]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:42:40 2007''
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Current revision

Conserved RNA Structure within the HCV IRES eIF3 Binding Site

PDB ID 1kp7

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