3h8d

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{{Seed}}
 
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[[Image:3h8d.jpg|left|200px]]
 
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==Crystal structure of Myosin VI in complex with Dab2 peptide==
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The line below this paragraph, containing "STRUCTURE_3h8d", creates the "Structure Box" on the page.
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<StructureSection load='3h8d' size='340' side='right'caption='[[3h8d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h8d]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H8D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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{{STRUCTURE_3h8d| PDB=3h8d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h8d OCA], [https://pdbe.org/3h8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h8d RCSB], [https://www.ebi.ac.uk/pdbsum/3h8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h8d ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE] Note=Defects in Myo6 are the cause of Snell's waltzer, a condition characterized by circling, head-tossing, deafness and hyperactivity.
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== Function ==
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[https://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h8d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h8d ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Myosin VI in complex with Dab2 peptide===
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==See Also==
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_19665975}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19665975 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19665975}}
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==About this Structure==
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3H8D is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H8D OCA].
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==Reference==
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<ref group="xtra">PMID:19665975</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Feng, W.]]
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[[Category: Feng W]]
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[[Category: Wei, Z.]]
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[[Category: Wei Z]]
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[[Category: Yu, C.]]
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[[Category: Yu C]]
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[[Category: Zhang, M.]]
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[[Category: Zhang M]]
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[[Category: Actin-binding]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: Cargo binding]]
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[[Category: Cell projection]]
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[[Category: Coated pit]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Dab2]]
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[[Category: Deafness]]
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[[Category: Disease mutation]]
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[[Category: Endocytosis]]
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[[Category: Golgi apparatus]]
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[[Category: Hearing]]
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[[Category: Membrane]]
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[[Category: Motor protein]]
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[[Category: Motor protein/signaling protein complex]]
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[[Category: Myosin]]
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[[Category: Myosin 6]]
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[[Category: Myosin vi]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Protein-peptide complex]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:12:22 2009''
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Current revision

Crystal structure of Myosin VI in complex with Dab2 peptide

PDB ID 3h8d

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