3icu

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{{Seed}}
 
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[[Image:3icu.jpg|left|200px]]
 
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==Protease-associated domain of the E3 ligase grail==
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The line below this paragraph, containing "STRUCTURE_3icu", creates the "Structure Box" on the page.
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<StructureSection load='3icu' size='340' side='right'caption='[[3icu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3icu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ICU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3icu| PDB=3icu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3icu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3icu OCA], [https://pdbe.org/3icu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3icu RCSB], [https://www.ebi.ac.uk/pdbsum/3icu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3icu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RN128_HUMAN RN128_HUMAN] E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity).<ref>PMID:12705856</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/3icu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3icu ConSurf].
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<div style="clear:both"></div>
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===Protease-associated domain of the E3 ligase grail===
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3ICU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICU OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Dhe-Paganon S]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Edwards AM]]
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[[Category: Seitova, A.]]
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[[Category: Seitova A]]
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[[Category: Walker, J R.]]
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[[Category: Walker JR]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Yermekbayeva, L.]]
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[[Category: Yermekbayeva L]]
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[[Category: Alternative splicing]]
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[[Category: Anergy]]
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[[Category: Cytoplasm]]
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[[Category: E3 ligase]]
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[[Category: Glycoprotein]]
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[[Category: Ligase]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Pa domain]]
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[[Category: Protein turnover]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transmembrane]]
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[[Category: Ubl conjugation]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:30:06 2009''
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Current revision

Protease-associated domain of the E3 ligase grail

PDB ID 3icu

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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