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2ffl
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2ffl.png|left|200px]] | ||
| - | + | ==Crystal Structure of Dicer from Giardia intestinalis== | |
| - | + | <StructureSection load='2ffl' size='340' side='right'caption='[[2ffl]], [[Resolution|resolution]] 3.33Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2ffl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. The February 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Small Interfering RNA'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_2 10.2210/rcsb_pdb/mom_2008_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.33Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffl OCA], [https://pdbe.org/2ffl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffl RCSB], [https://www.ebi.ac.uk/pdbsum/2ffl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffl ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/DCL_GIAIC DCL_GIAIC] Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.<ref>PMID:16410517</ref> | |
| - | + | == References == | |
| - | < | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Giardia intestinalis]] | [[Category: Giardia intestinalis]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Small Interfering RNA]] | [[Category: Small Interfering RNA]] | ||
| - | [[Category: Adams | + | [[Category: Adams PD]] |
| - | [[Category: Doudna | + | [[Category: Doudna JA]] |
| - | [[Category: MacRae | + | [[Category: MacRae IJ]] |
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Current revision
Crystal Structure of Dicer from Giardia intestinalis
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